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REVIEW article

Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1519273

The Interplay of Ferroptosis and Oxidative Stress in the Pathogenesis of Aortic Dissection

Provisionally accepted
Zhaoshan Zhang Zhaoshan Zhang 1,2Xi Kan Xi Kan 1,2*Xiaozhao Zhang Xiaozhao Zhang 1,2*Senping Xu Senping Xu 1,2*Zhengdong Wan Zhengdong Wan 1,2*Jiawei Guo Jiawei Guo 1,2*
  • 1 The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China
  • 2 Yangtze University, Jingzhou, Hubei Province, China

The final, formatted version of the article will be published soon.

    Aortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of the aortic media. Ferroptosis, a form of iron-dependent programmed cell death, occurs alongside lipid peroxidation and the accumulation of reactive oxygen species (ROS). The relationship between ferroptosis and AD lies in its damaging effect on vascular cells. In AD, ferroptosis worsens the damage to vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), thereby weakening the vascular wall's structural integrity and accelerating the onset and progression of the condition. However, the molecular mechanisms through which ferroptosis regulates the onset and progression of AD remain poorly understood. This article explores the relationship between ferroptosis and AD.

    Keywords: aortic dissection, ferroptosis, vascular smooth muscle cells, Oxidative Stress, ROS, Endothelial Cells

    Received: 29 Oct 2024; Accepted: 09 Jan 2025.

    Copyright: © 2025 Zhang, Kan, Zhang, Xu, Wan and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xi Kan, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China
    Xiaozhao Zhang, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China
    Senping Xu, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China
    Zhengdong Wan, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China
    Jiawei Guo, Yangtze University, Jingzhou, Hubei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.