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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1517964
This article is part of the Research Topic Herbal Medicines and Their Metabolites: Effects on Lipid Metabolic Disorders via Modulating Oxidative Stress - Volume II View all 6 articles

Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy

Provisionally accepted
Tianyao Gong Tianyao Gong 1Dongmei Wang Dongmei Wang 1,2*Jinyan Wang Jinyan Wang 1Qun Huang Qun Huang 3*Haiyan Zhang Haiyan Zhang 1*Chunmeng Liu Chunmeng Liu 1Xinglin Liu Xinglin Liu 4*Hejiang Ye Hejiang Ye 3*
  • 1 Eye School of Chengdu University of Traditional Chinese Medicine,, Chengdu, China
  • 2 School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
  • 3 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
  • 4 School of Management, Chengdu University of Traditional Chinese Medicine,, Chengdu, China

The final, formatted version of the article will be published soon.

    Diabetic retinopathy is the main microvascular complication of diabetes and the first blinding eye disease in the working-age population. Oxidative stress is an important pathogenesis of diabetic retinopathy. Plant metabolites can be divided into two types: primary metabolites and secondary metabolites, secondary metabolites are the main active components and important sources for developing new drugs. It has unique effect in the treatment of diabetic retinopathy. However, the research on the intervention mechanism of plant metabolites in diabetic retinopathy are still relatively shallow, which limit the application of plant metabolites. With the deepening of research, more and more plant metabolites have been reported to play a role in treating diabetic retinopathy through anti-oxidative stress, including polyphenols, polysaccharides, saponins, alkaloids, etc. Therefore, this article reviewed the potential of plant metabolites in the treatment of diabetic retinopathy in the last 10 years and elucidated their mechanism of action. We hope to provide some references for the application of plant metabolites and provide valuable resources for the research and development of new drugs for diabetic retinopathy.

    Keywords: plant metabolites, Oxidative Stress, Diabetic Retinopathy, Polyphenols, polysaccharide, Saponins, Alkaloids

    Received: 27 Oct 2024; Accepted: 14 Jan 2025.

    Copyright: © 2025 Gong, Wang, Wang, Huang, Zhang, Liu, Liu and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Dongmei Wang, Eye School of Chengdu University of Traditional Chinese Medicine,, Chengdu, China
    Qun Huang, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
    Haiyan Zhang, Eye School of Chengdu University of Traditional Chinese Medicine,, Chengdu, China
    Xinglin Liu, School of Management, Chengdu University of Traditional Chinese Medicine,, Chengdu, China
    Hejiang Ye, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.