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SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1508015
This article is part of the Research Topic Quality control for Efficacy and Safety of Herbal Medicinal Products: Volume II View all 13 articles
The efficacy and safety of Chinese herbal medicine Shugan Sanjie Decoction in the treatment of uterine fibroids a systematic review and meta-analysis
Provisionally accepted- Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
Background: Shugan Sanjie Decoction (SGSJ) is a commonly used Chinese medicine prescription for the treatment of uterine fibroids (UFs). However, there is still a lack of evidence for its effects and safety. To systematically assess the efficacy and safety of SGSJ in conjunction with Mifepristone [MFP] or Leuprolide acetate [LA] for the treatment of UFs, thereby providing a reference for clinical medication. Objective: To systematically assess the efficacy and safety of SGSJ in combination with MFP or LA for the treatment of UFs, thereby providing a basis for clinical medication decisions. Methods: Eight digital medical databases were systematically searched to identify randomized controlled trials (RCTs) evaluating the use of SGSJ combined with MFP or LA for the treatment of UFs. The search spanned from the inception of each database to July 2024. Risk of Bias (ROB) 2.0 and RevMan 5.3 software were utilized for systematic review and meta-analysis. Eligible studies
Keywords: Chinese herbal medicine, Shugan Sanjie Decoction, Uterine fibroids, Systematic review, Meta-analysis
Received: 08 Oct 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Zhang, Wei, Feng, Wang, Chai, Yuan and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuan Yuan, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong Province, China
Lirong Ren, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.