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REVIEW article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1507282

SOX9: A Key Transcriptional Regulator in Organ Fibrosis

Provisionally accepted
Yishuo Li Yishuo Li Yue Xing Yue Xing Ning Liu Ning Liu Bin Liu Bin Liu *Zhihui Wang Zhihui Wang *
  • Department of Cardiology, The Second Hospital of Jilin University, Changchun, Hebei Province, China

The final, formatted version of the article will be published soon.

    The SOX9 gene locus is not only extensive but also intricate, and it could promote fibrosis in different organs or tissues, including cardiac fibrosis, liver fibrosis, kidney fibrosis, pulmonary fibrosis, as well as other organ fibrosis. Many disorders are associated with the process of fibrosis; moreover, fibrosis is a common symptom of chronic inflammatory diseases, characterized by the accumulation of excessive components in the extracellular matrix through different signaling pathways. The advanced stage of the fibrotic process leads to organ dysfunction and, ultimately, death.In this review, we first give an overview of the original structure and functions of SOX9.Second, we will discuss the role of SOX9 in fibrosis in various organs or tissues. Third, we describe and reveal the possibility of SOX9 as an antifibrotic treatment target.Finally, we will focus on the application of novel technologies for SOX9 and the subsequent investigation of fibrosis.

    Keywords: SOX9, Fibrosis, cardiac fibrosis, liver fibrosis, renal fibrosis, Pulmonary Fibrosis

    Received: 07 Oct 2024; Accepted: 17 Jan 2025.

    Copyright: © 2025 Li, Xing, Liu, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bin Liu, Department of Cardiology, The Second Hospital of Jilin University, Changchun, Hebei Province, China
    Zhihui Wang, Department of Cardiology, The Second Hospital of Jilin University, Changchun, Hebei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.