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SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Infectious Diseases
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1505674
This article is part of the Research Topic Multidrug Resistant Bacteria: New Therapeutic Approaches for a Challenging Problem View all 3 articles
Global Trends in Antimicrobial Resistance of Enterococcus faecium: A Systematic Review and Meta-Analysis of Clinical Isolates
Provisionally accepted
Chen Huang 1
Samane Moradi 2
Mohammad Sholeh 3
Faezeh Motallebi Tabaei 2 Tingting Lai 1 Bo Tan 1* Jingjing Meng 4*
Khalil Azizian 5*- 1 Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
- 2 School of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan, Iran
- 3 Pasteur Institute of Iran (PII), Tehran, Tehran, Iran
- 4 Binzhou Polytechnic, Binzhou, Shandong Province, China
- 5 Kurdistan University of Medical Sciences, Sanandaj, Iran
Background: The multidrug resistant bacteria are associated with a high number of deaths and pose a significant global concern. In recent decades, among these resistant bacteria, Enterococcus faecium as a hospital-acquired pathogen has attracted more attention. Objective: In light of this, the present study aims to document the current state of resistance in E. faecium globally by considering several variables, including geographical locations, temporal trends, and sources of infection. Methods: We searched the studies in PubMed, Scopus, and Web of Science (November 30, 2022). All statistical analyses were carried out using the statistical package R. Results: Our meta-analysis of antibiotic resistance across various clinical isolates revealed substantial heterogeneity and variability. Average resistance proportions ranged from 2% for linezolid to 62.8% for erythromycin, with significant differences observed across different time periods, countries, and World Health Organization regional offices. Conclusion: Our findings confirm the high antibacterial activity of linezolid against E. faecium isolates. Additionally, our investigation reveals a gradual increase and concerning upward trend in resistance rates for nearly all agents in recent years. However, the significant reduction in resistance rates for certain antibiotics suggests that these drugs could potentially regain their effectiveness in the future.
Keywords: antimicrobial resistance, Enterococcus faecium, systematic review and meta-analysis, Vancocmyin, Clinical isolate bacterial
Received: 03 Oct 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Huang, Moradi, Sholeh, Tabaei, Lai, Tan, Meng and Azizian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bo Tan, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong Province, China
Jingjing Meng, Binzhou Polytechnic, Binzhou, Shandong Province, China
Khalil Azizian, Kurdistan University of Medical Sciences, Sanandaj, Iran
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