ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1505637
This article is part of the Research TopicCan Herbal Medicines and Their Metabolites Contribute to the Prevention and Treatment of Diabetic Kidney Disease (DKD)View all 3 articles
Regulation of autophagy by the PI3K-AKT pathway in Astragalus membranaceus -Cornus officinalis to ameliorate diabetic nephropathy
Provisionally accepted
- 1Renal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China, Harbin, China
- 2Changchun University of Chinese Medicine, Changchun, Jilin Province, China
- 3Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
- 4China-Japan Friendship Hospital, Beijing, Beijing Municipality, China
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Words:4569 the PI3K-AKT signaling pathway. In vivo experiments showed that AM-CO could induce autophagy, an increase in LC3II expression and a decrease in P62 expression.Meanwhile, in vitro experiments showed that Cal could also increase the expression of LC3II and inhibit the protein expression levels of p62, PI3K, P-AKT and AKT. The addition of a PI3K activator resulted in a reversal of protein expression.In conclusion, Cal can ameliorate the injury in DN by regulating autophagy, and PI3K-AKT is the main pathway for its regulation of autophagy and a key pathway for the action of AM-CO.
Keywords: diabetic nephropathy, Astragalus membranaceus -Cornus officinalis, Calycosin, lipidomic technology, Network analysis
Received: 03 Oct 2024; Accepted: 14 Apr 2025.
Copyright: © 2025 Zhang, Lan, Zhu, Wang, Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lifan Wang, Renal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China, Harbin, China
Peng Liu, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China
Ping Li, China-Japan Friendship Hospital, Beijing, 100029, Beijing Municipality, China
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