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REVIEW article
Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1493981
This article is part of the Research Topic Innovative Approaches and Molecular Mechanisms in Cardiovascular Pharmacology View all 6 articles
Acacetin as a Natural Cardiovascular Therapeutic: Mechanisms and Preclinical Evidence
Provisionally accepted
Zihe Zhou 1
Tao Li 2
Helin Qin 3 Xinyu Wang 2 Shanshan He 4 Zhongcai Fan 3
Qiang Ye 3*
Yanfei Du 2,3*- 1 Department of Clinical Medicine, School of Clinical Medicine, Southwest Medical University Luzhou, Sichuan, China, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
- 2 Key Laboratory of Medical Electrophysiology, Ministry of Education, Institute of Cardiovascular Medicine, Southwestern Medical University, Luzhou, Sichuan Province, China
- 3 Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
- 4 Department of Basic Medicine, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China
Globally, cardiovascular disease (CVD) has emerged as a leading cause of mortality and morbidity. As the world's population ages, CVD incidence is on the rise, and extensive attention has been drawn to optimizing the therapeutic regimes. Acacetin, a natural flavonoid derived from various plants, has been demonstrated to have a wide spectrum of pharmacological properties, such as antioxidant, anti-inflammatory, antibacterial, and anti-tumor activities, as well as protective effects on diverse tissues and organs. Recently, increasing studies (mostly preclinical) have indicated that acacetin has potential cardiovascular protective effects and might become a novel therapeutic
Keywords: Acacetin, Flavonoids, cardiovascular disease, cardiovascular protective effects, Potential mechanisms
Received: 10 Sep 2024; Accepted: 06 Feb 2025.
Copyright: © 2025 Zhou, Li, Qin, Wang, He, Fan, Ye and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiang Ye, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Yanfei Du, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.