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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1491935
Metabolomics of the effects of Yishenjiangya granules in older adults with hypertension
Provisionally accepted- 1 Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 3 Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
Older adults are a high-risk group for hypertension, with specific characteristics regarding symptoms and treatment. Yishenjiangya granules (YJG), a traditional Chinese medicinal decoction, are widely used to reduce blood pressure and improve clinical symptoms. This study aimed to use metabolomics to explore the clinical effects and underlying mechanisms of YJG in hypertension in older adults.The study enrolled patients aged ≥65 years, with systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg in sitting positions on different days; the control group comprised 30 healthy participants with normal blood pressure and biochemistry indicators. Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was used to analyze plasma metabolites in patients with hypertension before and after YJG intervention.Results: After YJG treatment, blood pressure decreased significantly; some metabolites showed a trend approaching the control group. UPLC-Q-TOF-MS analysis identified 30 YJG-targeted plasma metabolites in older adult patients with hypertension, including three major metabolic pathways: linoleic acid, arachidonic acid, and glycerophospholipid metabolism.This study identified that metabolite changes may underlie the clinical mechanism of YJG in treating older adult patients with hypertension, providing a basis for further treatment of hypertension.
Keywords: Hypertension, Yishenjiangya granules, Metabolomics, Linoleic Acid, Arachidonic Acid, Glycerophospholipid
Received: 05 Sep 2024; Accepted: 17 Feb 2025.
Copyright: © 2025 Ma, Liu, Zhuang, Dai, Yao, Yu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lei Zhang, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, Shandong Province, China
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