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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1482172
Quercitrin, the primary active ingredient of Albizia julibrissin Durazz. flowers, alleviates methamphetamine-induced hepatotoxicity through a mitochondria-mediated apoptosis pathway
Provisionally accepted
Dan Wu 1* Bo Xie 2* Jing Li 1*
Zhangang Xiao 2
Jing Shen 2
XU WU 3 Mingxing Li 3* Hongping Shen 1*
Qin Sun 1 Yong Dai 4*
Yueshui Zhao 3*- 1 Integrated Chinese and Western Medicine School, Southwest Medical University, Luzhou, China
- 2 School of Pharmacy, Southwest Medical University, Luzhou, China
- 3 Southwest Medical University, Luzhou, China
- 4 Sichuan Police College, Luzhou, China
Background and purpose: Methamphetamine (METH), a synthetic psychostimulant and highly addictive drug, could cause depression and acute liver injury. There have been few studies on the mechanism by which METH induces liver damage and on how to alleviate METH-induced hepatic toxicities.Durazz. flowers (AF) is a traditional Chinese medicine known for its ability to releve depression and soothe the liver. The extracts of AF have shown hepatoprotective effects with their anti-oxidative activities. The potential of AF extracts to alleviate METH-induced hepatic toxicity remains unclear.This study aims to investigate the effects of AF extracts and their priamry active ingredient on METH-induced hepatotoxicity and explore the potential underlying mechanisms. Methods: Firstly, we used the MTT assay to screen the active components of AF. Then, UPLC-MS/MS was employed to analyze the effective components and identify their activities. In addition, in vitro and in vivo experiments were conducted to explore the effects of the active components on METH-induced hepatic toxicity. Moreover, flow cytometry was employed to detect the effects s 删除[庐外先生老赵]: , 删除[庐外先生老赵]:
Keywords: quercitrin, Oxidative damage, Hepatotoxicity, ROS, Apoptosis
Received: 22 Aug 2024; Accepted: 13 Feb 2025.
Copyright: © 2025 Wu, Xie, Li, Xiao, Shen, WU, Li, Shen, Sun, Dai and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dan Wu, Integrated Chinese and Western Medicine School, Southwest Medical University, Luzhou, China
Bo Xie, School of Pharmacy, Southwest Medical University, Luzhou, China
Jing Li, Integrated Chinese and Western Medicine School, Southwest Medical University, Luzhou, China
Mingxing Li, Southwest Medical University, Luzhou, China
Hongping Shen, Integrated Chinese and Western Medicine School, Southwest Medical University, Luzhou, China
Yong Dai, Sichuan Police College, Luzhou, China
Yueshui Zhao, Southwest Medical University, Luzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.