ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1474265
This article is part of the Research TopicAcute and Chronic Lung Injury: Therapeutic Targets and DrugsView all 6 articles
Triglyceride-Glucose Index as an Independent Predictor of Mortality in Patients with Chronic Respiratory Diseases
Provisionally accepted
- Shenzhen Guangming District People's Hospital, Shenzhen, China
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The consequences of chronic pulmonary illness are known to exacerbate in individuals with metabolic syndrome and insulin resistance. However, the relationship between triglycerideglucose (TyG) index, a reliable alternative biomarker of metabolic dysfunction, and chronic respiratory diseases (CRDs) are inconclusive.Our research involved a total of 7,819 adult individuals diagnosed with CRDs who participated in the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018. To assess the correlation between the TyG index and survival rates, we employed multivariable weighted Cox regression analysis, smoothing curve fitting, survival curve analysis and subgroup analysis to investigate the relationship.Higher TyG index among CRDs shown a substantial positive correlation with all-cause mortality after controlling for relevant confounders. The restricted cubic spline analysis showed a nonlinear relationship between the TyG score and all-cause mortality in CRDs.Patients with higher TyG indexes had a greater risk of all-cause mortality according to Kaplan-Meier survival curves.The clinical relevance of the TyG index in predicting the life expectancy of individuals with CRDs is highlighted by our research. The TyG index can serve as a substitute biomarker for monitoring the well-being of the individuals with CRDs.
Keywords: Triglyceride-glucose index, Mortality, chronic respiratory diseases, NHANES, risk prediction
Received: 01 Aug 2024; Accepted: 21 Apr 2025.
Copyright: © 2025 Lu, Jiang, Li and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Feng Xu, Shenzhen Guangming District People's Hospital, Shenzhen, China
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