AUTHOR=Pilalis Eleftherios , Zisis Dimitrios , Andrinopoulou Christina , Karamanidou Theodora , Antonara Maria , Stavropoulos Thanos G. , Chatziioannou Aristotelis TITLE=Genome-wide functional annotation of variants: a systematic review of state-of-the-art tools, techniques and resources JOURNAL=Frontiers in Pharmacology VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1474026 DOI=10.3389/fphar.2025.1474026 ISSN=1663-9812