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REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1472804
This article is part of the Research Topic The Molecular Mechanism in Anti-tumor Therapy Resistance View all 13 articles
Mitochondria-associated non-coding RNAs and their impact on drug resistance
Provisionally accepted- 1 Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin Province, China
- 2 First Affiliated Hospital of Jilin University, Changchun, China
- 3 The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China
Drug resistance is a prevalent challenge in clinical disease treatment, often leading to disease relapse and poor prognosis. Therefore, it is crucial to gain a deeper understanding of the molecular mechanisms underlying drug resistance and to develop targeted strategies for its effective prevention and management. Mitochondria, as vital energy-producing organelles within cells, have been recognized as key regulators of drug sensitivity. Processes such as mitochondrial fission, fusion, mitophagy, changes in membrane potential, reactive oxygen species (ROS) accumulation, and oxidative phosphorylation (OXPHOS) are all linked to drug sensitivity. Non-coding RNAs (ncRNAs) enriched in mitochondria (mtncRNA), whether transcribed from mitochondrial DNA (mtDNA) or from the nucleus and transported to mitochondria, can regulate the transcription and translation of mtDNA, thus influencing mitochondrial function, including mitochondrial substance exchange and energy metabolism. This, in turn, directly or indirectly affects cellular sensitivity to drugs. This review summarizes the types of mtncRNAs associated with drug resistance and the molecular mechanisms regulating drug resistance. Our aim is to provide insights and strategies for overcoming drug resistance by modulating mtncRNAs.
Keywords: Mitochondria, microRNA, lncRNA, Drug Resistance, Cancer
Received: 30 Jul 2024; Accepted: 07 Feb 2025.
Copyright: © 2025 An, Sun, Zheng, Xiao, Sun and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weixia Sun, First Affiliated Hospital of Jilin University, Changchun, China
Dehai Yu, First Affiliated Hospital of Jilin University, Changchun, China
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