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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1469949
Integrative Analysis of Anti-Breast CancerPotential of Metabolites from Pseudomonas frederiksbergensis Isolated from Taoerqi
Provisionally accepted
Yuexing Ma 1,2,3*
Haoyi Zheng 1
Simin Liu 1* En Yuan 4* Xin Qiao 4* Zhang Dai 4* Wenli Wu 4* Rongbin Pan 4*- 1 School of Science and Technology, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
- 2 China Pharmaceutical University, Nanjing, Jiangsu Province, China
- 3 Nanchang Medical College, Nanchang, Jiangxi Province, China
- 4 Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China
The Tibetan medicinal botanical drug Taoerqi has long been recognized for its anti-inflammatory, antibacterial, and tumor-inhibitory properties. Botanical drug focuses on the isolation and characterization of secondary metabolites from Pseudomonas frederiksbergensis, an endophytic bacterium isolated from Taoerqi roots. The metabolites were obtained through fermentation and purification processes and were evaluated for their anti-breast cancer activities using cellular assays and transcriptomic analysis. Key regulatory targets, including SARM1, RGS5, PROM2, and BAG1, were identified through bioinformatics analysis and validated using qPCR and Western blotting. Furthermore, a clinical risk assessment model was constructed using breast cancer transcriptome databases to explore the potential prognostic value of these targets. Our findings reveal that the secondary metabolites from Pseudomonas frederiksbergensis exhibit significant anti-tumor effects and highlight their potential molecular mechanisms in breast cancer regulation. This study provides insights into the therapeutic potential of these metabolites and lays the groundwork for future preclinical and in vivo investigations.
Keywords: Taoerqi, Pseudomonas frederiksbergensis, Endophytic metabolites, breast cancer, CancerPotential
Received: 12 Aug 2024; Accepted: 16 Jan 2025.
Copyright: © 2025 Ma, Zheng, Liu, Yuan, Qiao, Dai, Wu and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuexing Ma, School of Science and Technology, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
Simin Liu, School of Science and Technology, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
En Yuan, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi Province, China
Xin Qiao, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi Province, China
Zhang Dai, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi Province, China
Wenli Wu, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi Province, China
Rongbin Pan, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi Province, China
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