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REVIEW article
Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1464498
This article is part of the Research Topic Gastrointestinal Damage and Metabolic Disorders View all 8 articles
The potential of Sijunzi decoction in the fight against gastrointestinal disorders: A review
Provisionally accepted- 1 Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, China
- 2 Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
Sijunzi Decoction (SJZD) is a traditional Chinese medicine formula widely used in the treatment of gastrointestinal disorders. Clinical studies have substantiated the efficacy of SJZD in managing conditions such as functional dyspepsia, chronic gastritis, gastric cancer, irritable bowel syndrome, colorectal cancer, and ulcerative colitis. Despite its proven effectiveness, the precise mechanisms by which SJZD operates remain incompletely understood. In this study, we undertake a systematic review of both the clinical applications and the mechanistic underpinnings of SJZD in the context of gastrointestinal disease treatment. Researches indicatesd that SJZD functions through a spectrum of mechanisms including the regulation of intestinal flora, alleviation of inflammation, modulation of immune responses, and facilitation of mucosal repair in the treatment of gastrointestinal ailments. This comprehensive analysis aims to provide a clearer understanding of how SJZD benefits patients with gastrointestinal disorders.
Keywords: Sijunzi decoction (SJZD), gastrointestinal disorders, Traditional Chinese, functional dyspepsia, Irritable Bowel Syndrome, tumor
Received: 14 Jul 2024; Accepted: 03 Feb 2025.
Copyright: © 2025 Yang, Fang, Zhu, Li, Yang, Liu and Lou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zheng Fang, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang Province, China
Xiaofang Li, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong Province, China
Haiyan Liu, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang Province, China
Feiyan Lou, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang Province, China
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