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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1452797
This article is part of the Research Topic Natural Products in Medicine: Insights from History and Ethnopharmacology View all 12 articles
Clerodendranthus spicatus: a comprehensive review of the chemical constituents, pharmacology, quality control and clinical applications
Provisionally accepted- 1 Yunnan Yunzhong Institute of Nutrition and Health，Yunnan University of Chinese Medicine, Kunming, China
- 2 Kunming Medical University, Kunming, Yunnan Province, China
Clerodendranthus spicatus (CS), is an herbaceous perennial belonging to the family Lamiaceae. The herb is extensively employed in traditional Chinese medicine for the mitigation of nephritis, cystitis, kidney stones, urological tract stones, gout, and other urinary conditions. Numerous research studies have been conducted in the past to explore the traditional medicinal value, phytochemical composition, pharmacological effects, and quality control measures associated with this plant. This has motivated us to systematically search various online databases such as Google Scholar, PubMed, Science Direct, Elsevier, CNKI, Scopus, Embase, and Web of Science using specific keywords to get the most recent research information findings related to this plant. Phytochemical investigations have identified that this plant predominantly contains flavonoids, terpenoids, phenylpropanoids, and volatile oil compounds. Certain constituents have been employed as markers in quality assessment research, and some were recognized as bioactive agents in the management of specific ailments. These components have demonstrated notable effectiveness in combating bacterial infections, reducing inflammation, providing antioxidant properties, managing hyperuricemia, and offering renal protection. Notably, clinical trials have confirmed its remarkable efficacy in treating urinary inflammation and stones. We acquired recent research findings concerning CS in the fields of phytochemistry, pharmacology, quality control, and clinical applications via online search. These findings have been summarized and analysed to offer a valuable reference for further comprehensive research, development, and utilization of CS.
Keywords: Clerodendranthus spicatus, Chemical constituents, Pharmacology, review, Quality control, clinical application
Received: 21 Jun 2024; Accepted: 21 Feb 2025.
Copyright: © 2025 Liu, Jiao, Jin, Zhu, Tan and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lu Liu, Yunnan Yunzhong Institute of Nutrition and Health，Yunnan University of Chinese Medicine, Kunming, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.