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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1539363
This article is part of the Research Topic Promising Photosensitive Agents for Photodynamic Therapy View all 4 articles

Photodynamic therapy with a novel photosensitizer inhibits DSSinduced ulcerative colitis in rats via the NF-κB signaling pathway

Provisionally accepted
Yu Mei Rong Yu Mei Rong 1,2,3Mei Hui Zhu Mei Hui Zhu 1,2,3*Nang Wang Nang Wang 1,2,3*Feiyu Zhang Feiyu Zhang 1,2,3Tian Jun Liu Tian Jun Liu 4*
  • 1 The Third Central Hospital of Tianjin, tiajin, China
  • 2 Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, tianjin, China
  • 3 Artificial Cell Engineering Technology Research Center, tianjin, China
  • 4 Tianjin Key Laboratory of Biomedical Material, Institute of Biomedical Engineering, tianjin, China

The final, formatted version of the article will be published soon.

    Ulcerative colitis (UC) is an inflammatory bowel disease characterized by inflammation and ulceration of the digestive tract. This study aimed to investigate the potential role and mechanisms of LD4-PDT in dextran sulfate sodium (DSS)-induced UC. Our findings indicate that LD4-PDT could protect the integrity of the colonic mucosa, alleviate the inflammatory response and promote the healing of colonic mucosa. Mechanism studies demonstrated that LD4-PDT could inhibit the NF-κB signaling pathway, downregulated the expression of the inflammatory factors tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and myeloperoxidase (MPO), increased the contents of glutathione (GSH) and superoxide oxidase (SOD) and decreased the content of malondialdehyde (MDA). Additionally, analysis of gut microbiota revealed that LD4-PDT treatment could decrease the abundance of the Proteobacteria phylum in fecal samples, while no significant differences were observed in the Firmicutes, Bacteroidetes, or Actinobacteria phyla among the three groups using 16S rRNA analysis. In summary, our data suggested that LD4-PDT could inhibit DSS -induced UC in rats via the NF-κB signaling pathway, indicating its potential as a novel photosensitizer for the treatment of UC.

    Keywords: ulcerative colitis, DSS, Oxidative Stress, NF-κB signaling pathway, Gut microbiota Ulcerative colitis, NF-κB signaling pathway, Gut microbiota

    Received: 04 Dec 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Rong, Zhu, Wang, Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Mei Hui Zhu, The Third Central Hospital of Tianjin, tiajin, China
    Nang Wang, Artificial Cell Engineering Technology Research Center, tianjin, China
    Tian Jun Liu, Tianjin Key Laboratory of Biomedical Material, Institute of Biomedical Engineering, tianjin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.