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REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Ion Channels and Channelopathies
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1536864
This article is part of the Research Topic Epithelial Transport: from fluid movement toward system organization View all articles

The enigmatic SLC26A6 multifunctional anion transporter: Recent advances in structure-function relationship, pathophysiological significance and novel pharmacological a

Provisionally accepted
Ursula E. Seidler Ursula E. Seidler *
  • Hannover Medical School, Hanover, Germany

The final, formatted version of the article will be published soon.

    SLC26A6, a member of the SLC26 family of multifunctional anion transporters, has been particularly enigmatic because of its multiple modes of transport, its expression in organs that are difficult to study physiologically, and the lack of specific antibodies and inhibitors. This has recently changed. SLC26A6 is expressed in the human pancreas, kidney, intestine, heart and some other organs and is involved in fluid absorption, anion secretion, regulation of intracellular pH and elimination of waste products such as oxalate.

    Keywords: anion exchange, Cryo-microscopy, SLC26 family, Hyperuricemia, Nephrolithiasis, pancreatic secretion, Acid base balance, intestine

    Received: 29 Nov 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 Seidler. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ursula E. Seidler, Hannover Medical School, Hanover, Germany

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