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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1536764
This article is part of the Research Topic Advanced Therapeutic Strategies in Digestive and Circulatory Health: Nanomedicine and Beyond View all 3 articles

Enhanced Antitumor Efficacy through Sustained Release of 5-Fluorouracil from Poly(trimethylene carbonate) Membranes

Provisionally accepted
Zongheng Wang Zongheng Wang 1Zhipeng Hou Zhipeng Hou 2*Shuguang Zhang Shuguang Zhang 3Shuangyi Ren Shuangyi Ren 1*Liqun Yang Liqun Yang 2*Qianshi Zhang Qianshi Zhang 1*
  • 1 Department of Gastrointestinal Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
  • 2 Research Center for Biomedical Materials, Shengjing Hospital of China Medical University, Shenyang, China
  • 3 The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Cancer remains one of the deadliest diseases worldwide. 5-Fluorouracil(5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes. This study aimed to develop a Poly(trimethylene carbonate)(PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. The membranes were prepared using the solvent-casting method, and their comprehensive properties were characterized. We evaluated the in vitro sustained release capability, as well as the biocompatibility and antitumor activity at both cellular and animal levels. The results demonstrated that the 5-FU-loaded PTMC membranes exhibited effective sustained release capabilities, superior biocompatibility, and enhanced antitumor effects compared to the 5-FU injections. These findings suggested that the 5-FU-loaded PTMC membranes hold great potential for application in cancer patients, offering benefits in chemotherapy treatment.

    Keywords: Poly(trimethylene carbonate), Sustained drug release system, 5-fluorouracil, colorectal cancer, Antitumor efficacy

    Received: 29 Nov 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 Wang, Hou, Zhang, Ren, Yang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhipeng Hou, Research Center for Biomedical Materials, Shengjing Hospital of China Medical University, Shenyang, China
    Shuangyi Ren, Department of Gastrointestinal Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
    Liqun Yang, Research Center for Biomedical Materials, Shengjing Hospital of China Medical University, Shenyang, China
    Qianshi Zhang, Department of Gastrointestinal Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.