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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1521040
A review of Psoralea corylifolia L.: A valuable plant with profound biological significance
Provisionally accepted- 1 Heilongjiang University of Chinese Medicine, Harbin, China
- 2 Qingyuan People's Hospital, Qingyuan, China
- 3 Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China
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Psoralea corylifolia L. (PCL) is an annual herb of the genus Psoralea in the family Fabaceae, and its mature fruit can be used medicinally as a precious medicinal herb to tonify muscles and bones. With the deepening of research, its applications to various industries, including food, agriculture, and cosmetics, with products being developed in countries such as Vietnam, India, and Japan. A total of 321 metabolites, including coumarins, flavonoids, meroterpenes, benzofurans, and dimers, were identified in PCL. PCL and related products have demonstrated therapeutic effects, such as antiosteoporosis effects, estrogen-like effects, anti-inflammatory properties, neuroprotection, antitumor activity, and vitiligo treatment. The expression mechanisms of these pharmacological effects are closely related to the regulation of the immune system, the inhibition of oxidative stress, and the induction of apoptosis. This paper summarizes the latest research on the ethnobotany, phytochemistry, processing technology, pharmacology, and hepatotoxicity of PCL. Furthermore, bibliometric analysis was used to systematically analyze the research hotspots and trends in PCL, which have never been addressed in previous reviews of PCL. In the future, it will be necessary to focus on the active metabolites of PCL, analyze its targets and signaling pathway network to address potential toxicity and side effects in clinical applications, and further expand the potential application of PCL in medicine.
Keywords: Psoralea corylifolia L., Ethnobotany, phytochemistry, Pharmacological effects, Hepatotoxicity
Received: 01 Nov 2024; Accepted: 17 Dec 2024.
Copyright: © 2024 Yang, Kong, You, Li, Guan, Li, Zhong and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hai Jiang, Heilongjiang University of Chinese Medicine, Harbin, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.