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REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1516650

Metabolic Reprogramming in Lung cancer and its clinical implication

Provisionally accepted
Qingqiu Huang Qingqiu Huang 1Lisha Fan Lisha Fan 2*Mingjing Gong Mingjing Gong 3*Juntong Ren Juntong Ren 4*Chen Chen Chen Chen 5*Shenglong Xie Shenglong Xie 1*
  • 1 Department of Thoracic Surgery, Sichuan Provincial People's Hospital, Chengdu, China
  • 2 Department of Respiratory and Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China
  • 3 The First Veterans Hospital of Sichuan Province, China, China
  • 4 School of Medicine, Guizhou University, Guiyang, Guizhou Province, China
  • 5 Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Lung cancer has posed a significant challenge to global health, and related study has been a hot topic in oncology. This article focuses on metabolic reprogramming of lung cancer cells, a process to adapt to energy demands and biosynthetic needs, supporting the proliferation and development of tumor cells. In this study, the latest studies on lung cancer tumor metabolism were reviewed, including the impact of metabolic products and metabolic enzymes on the occurrence and development of lung cancer, as well as the progress in the field of lung cancer treatment targeting relevant metabolic pathways. This provides some promising potential directions into exploring lung cancer tumor metabolism and helps researchers to better understand lung cancer.

    Keywords: metabolic reprogramming, lung cancer, Glucose, Lipid Metabolism, amino acid metabolism

    Received: 24 Oct 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Huang, Fan, Gong, Ren, Chen and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lisha Fan, Department of Respiratory and Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 611731, Sichuan Province, China
    Mingjing Gong, The First Veterans Hospital of Sichuan Province, China, China
    Juntong Ren, School of Medicine, Guizhou University, Guiyang, 550025, Guizhou Province, China
    Chen Chen, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 611731, Sichuan Province, China
    Shenglong Xie, Department of Thoracic Surgery, Sichuan Provincial People's Hospital, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.