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REVIEW article

Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1516469
This article is part of the Research Topic Clinical Pharmacist Service Promotes the Improvement of Medical Quality Volume II View all 33 articles

Discussion on the optimization of personalized medication using information systems based on pharmacogenomics: an example using colorectal cancer

Provisionally accepted
Mengying Yuan Mengying Yuan 1Yuankun Zheng Yuankun Zheng 1Niuniu Bai Niuniu Bai 1,2Fei Wang Fei Wang 1Haoling Zhang Haoling Zhang 3Bian Yuan Bian Yuan 1,4Hao Liu Hao Liu 5*Xia He Xia He 1,4*
  • 1 Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China
  • 2 Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi Province, China
  • 3 Department of Pharmacy, Yuncheng Central Hospital, Shanxi Medical University, Yuncheng, Shanxi Province, China
  • 4 Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
  • 5 Department of Oncology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Pharmacogenomics (PGx) is a powerful tool for clinical optimization of drug efficacy and safety.However, due to many factors affecting drugs in the real world, PGx still accounts for a small proportion of actual clinical application scenarios. Therefore, based on the information software, pharmacists use their professional advantages to integrate PGx into all aspects of pharmaceutical care, which is conducive to promoting the development of personalized medicine. In this paper, the establishment of an information software platform is summarized for the optimization of a personalized medication program based on PGx. Taking colorectal cancers (CRC) as an example, this paper also discusses the role of PGx in different working modes and participation in drug management of CRC patients by pharmacists with the help of information systems. Finally, we summarized the recommendations of different PGx guidelines to provide reference for the follow-up personalized pharmaceutical care.

    Keywords: pharmacogenomics, colorectal cancer, Personalized medication, Information System, Pharmaceutical service

    Received: 24 Oct 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Yuan, Zheng, Bai, Wang, Zhang, Yuan, Liu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hao Liu, Department of Oncology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan Province, China
    Xia He, Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 611731, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.