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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Renal Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1510477

Hypoalbuminemia And Cisplatin-Induced Acute Kidney Injury: A Multi-Source Data Analysis

Provisionally accepted
Yujie Huang Yujie Huang 1Wen-jun Yin Wen-jun Yin 1qing zhu qing zhu 2xiaoqing lin xiaoqing lin 1huiling piao huiling piao 1qianqian yu qianqian yu 1changhong lai changhong lai 1guangliang zhou guangliang zhou 1Ling-Yun Zhou Ling-Yun Zhou 1Shanru Zuo Shanru Zuo 1kun liu kun liu 1Xiao-Cong Zuo Xiao-Cong Zuo 1*
  • 1 Third Xiangya Hospital, Central South University, Changsha, China
  • 2 Hunan Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China

The final, formatted version of the article will be published soon.

    Background: Cisplatin binds to serum albumin in the body at a rate of 90%, and high levels of free cisplatin are a significant cause of its nephrotoxicity. Therefore, hypoalbuminemia theoretically poses a significant risk factor for cisplatin-induced acute kidney injury (CIA) and can be easily corrected. However, existing research results are inconsistent. Our aim is to confirm the association between hypoalbuminemia and CIA through a meta-analysis and a dual-center real-world data study. Methods: First, we used a random-effects meta-analysis to summarize the odds ratio (OR) of the risk relationship between hypoalbuminemia and CIA. Then, we conducted a retrospective analysis of patients using cisplatin from Xiangya Third Hospital of Central South University (2014-2023) and Hunan Cancer Hospital (2019-2023) to analyze the relationship between hypoalbuminemia and CIA. Results: The meta-analysis, which included six studies involving 4,359 cases, showed that hypoalbuminemia is associated with an increased risk of CIA (OR, 2.13; 95% CI,. A total of 5,452 and 25,214 patients from Xiangya Third Hospital and Hunan Cancer Hospital, respectively, were included. Both centers found a significant association between hypoalbuminemia and an increased risk of CIA (OR, 2.76; 95% CI, 1. OR, 3.76; 95% CI,, and the sensitivity analysis results were consistent. Conclusion: Through meta-analysis and dual-center realworld data studies, we confirmed that hypoalbuminemia is an independent risk factor for CIA. Therefore, it is recommended that patients using cisplatin undergo serum albumin level testing and regular monitoring during treatment. Actively adjusting albumin levels may reduce the risk of CIA.

    Keywords: Cisplatin, Acute Kidney Injury, Hypoalbuminemia, Meta-analysis, Retrospective study

    Received: 13 Oct 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Huang, Yin, zhu, lin, piao, yu, lai, zhou, Zhou, Zuo, liu and Zuo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiao-Cong Zuo, Third Xiangya Hospital, Central South University, Changsha, China

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