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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1510307

Exploratory review on the effect of Astragalus mongholicus on signaling pathwaysEffect of Astragalus membranaceus explained according to signaling pathways. A review

Provisionally accepted
Inmaculada Xu Lou Inmaculada Xu Lou Xinyi Yu Xinyi Yu Qilan Chen Qilan Chen *
  • Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China

The final, formatted version of the article will be published soon.

    ABSTRACT Background: Astragalus membranaceusAstragalus mongholicus Bunge [Fabaceae; Astragali radix]) (AM), a traditional Chinese medicinal (TCM) botanical drugherb, has been used for centuries and has gained increasing attention in medical research due to its therapeutic potential. This review article analyzes the most relevant scientific studies on AMastragalus, including its chemical composition, mechanisms of action, and health benefits. Main body: AMAstragalus membranaceus is commonly used in clinical practice to treat diabetes mellitus, cardiovascular diseases, oncological processes, lipid metabolism disorders, and ulcerative colitis. Recent research has investigated its potential as a product for anti-aging purposes. These therapeutic effects are attributed to the interactions of bioactive metabolitescompounds such as Astragaloside IV, Formononetin, and polysaccharides, with various signaling pathways, leading to the activation or inhibition of gene expression. This review aims to map the signaling pathways affected by these metabolitescompounds and their effects on different pathologies. Studies suggest that these metabolitescompounds act on signaling pathways such as TLR4/MyD88/NF-κB, PI3K/AKT, RNA expression, and tumor receptors. However, further research is necessary to validate the findings in human trials with better methodological quality. Conclusion: Astragalus membranaceusAM is rich in bioactive metabolitescompounds that interact with various signaling pathways, modulating diseases such as diabetes mellitus type 2, cardiovascular diseases, cancer, lipid metabolism disorders, and ulcerative colitis. Although promising, the majority of the studies are conducted in vitro and animal models, and more rigorous human trials are needed to determine the therapeutic potential of AMAstragalus membranaceus.

    Keywords: Astragalus membranaceusmongholicus, Signaling Pathways, Astragaloside IV, Formononetin, Polysaccharides

    Received: 12 Oct 2024; Accepted: 27 Nov 2024.

    Copyright: © 2024 Xu Lou, Yu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qilan Chen, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.