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REVIEW article

Front. Pharmacol.
Sec. Inflammation Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1509172

Decoding Ferroptosis: Transforming Orthopedic Disease Management

Provisionally accepted
Guanlin Huo Guanlin Huo 1Yumeng Lin Yumeng Lin 2Lusheng Liu Lusheng Liu 3Yuqi He Yuqi He 4Yi Qu Yi Qu 1Yang Liu Yang Liu 1Renhe Zhu Renhe Zhu 4Bo Wang Bo Wang 5Qing Gong Qing Gong 1Zhongyu Han Zhongyu Han 1*Hongbing Yin Hongbing Yin 1
  • 1 Changchun University of Chinese Medicine, Changchun, Jilin Province, China
  • 2 Nanjing Tongren Hospital, Nanjing, Liaoning Province, China
  • 3 Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
  • 4 Anhui Medical University, Hefei, Anhui Province, China
  • 5 Eighth Medical Center of the General Hospital of the Chinese People's Liberation Army, Beijing, Beijing, China

The final, formatted version of the article will be published soon.

    As a mechanism of cell death, ferroptosis has gained popularity since 2012. The process is distinguished by iron toxicity and phospholipid accumulation, in contrast to autophagy, apoptosis, and other cell death mechanisms. It is implicated in the advancement of multiple diseases across the body. Researchers currently know that osteosarcoma, osteoporosis, and other orthopedic disorders are caused by NRF2, GPX4, and other ferroptosis star proteins. The effective relief of osteoarthritis symptoms from deterioration has been confirmed by clinical treatment with multiple ferroptosis inhibitors. At the same time, it should be reminded that the mechanisms involved in ferroptosis that regulate orthopedic diseases are not currently understood. In this manuscript, we present the discovery process of ferroptosis, the mechanisms involved in ferroptosis, and the role of ferroptosis in a variety of orthopedic diseases. We expect that this manuscript can provide a new perspective on clinical diagnosis and treatment of related diseases.

    Keywords: Lipid Peroxidation, antioxidant system, iron metabolism, Orthopedic disorders, mechanisms, therapy

    Received: 10 Oct 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Huo, Lin, Liu, He, Qu, Liu, Zhu, Wang, Gong, Han and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhongyu Han, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.