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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1507326
This article is part of the Research Topic Cardiometabolic Diseases: Therapeutic Targets Discovery and Mechanism Study View all 9 articles

Comparative Analysis of Mineralocorticoid Receptor Antagonists and Renin-Angiotensin System Inhibitors/Angiotensin Receptor Neprilysin Inhibitor in Heart Failure with Mildly Reduced Ejection Fraction

Provisionally accepted
ChiaChen Lee ChiaChen Lee Te-Wei David Te-Wei David Kai-Chun Chang Kai-Chun Chang Ting-Tse Lin Ting-Tse Lin *Cho-Kai Wu Cho-Kai Wu Lian-Yu Lin Lian-Yu Lin
  • National Taiwan University Hospital, Taipei, Taiwan

The final, formatted version of the article will be published soon.

    Figure : 3 0.78-1.02) or HHF (hazard ratio = 1.01, 95% CI: 0.94-1.09). Conversely, RASI//ARNI use was linked to a lower risk of cardiovascular death (hazard ratio = 0.82, 95% CI: 0.71-0.94) but not HHF (hazard ratio = 0.995, 95% CI: 0.924-1.07).Landmark analysis showed no significant difference in outcomes for follow-up durations exceeding two years.MRA had a neutral effect on cardiovascular death and HHF, while RASI/ARNI was associated with a lower risk of cardiovascular death. RASI/ARNI may be more beneficial than MRA for HFmrEF patients. Regular re-evaluation is essential to adjust heart failure treatment.

    Keywords: HFmrEF, cardiovascular outcomes, reninangiotensin system inhibitor, Angiotensin receptor neprilysin inhibitor, MRA (magnetic resonance angiography)

    Received: 07 Oct 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Lee, David, Chang, Lin, Wu and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ting-Tse Lin, National Taiwan University Hospital, Taipei, Taiwan

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