AUTHOR=Zou Yutao , Wu Junjie , Zhang Qiuyun , Chen Jiayi , Luo Xuanxuan , Qu Yijie , Xia Rui , Wang Weiqi , Zheng Xiaohua TITLE=Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy JOURNAL=Frontiers in Pharmacology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1505212 DOI=10.3389/fphar.2024.1505212 ISSN=1663-9812 ABSTRACT=
Porphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). However, porphyrin based nMOFs (por-nMOFs) still face challenges such as rapid immune clearance and weak tumor targeting. Researchers have discovered that using a top-down biomimetic strategy, where nMOFs are coated with cell membranes, can promote long blood circulation, evade the reticuloendothelial system, and improve cancer cell targeting, thereby significantly enhancing the photodynamic therapy (PDT) effect of nMOFs. This review summarizes the recent work on different cell membranes-coated por-nMOFs for enhanced tumor PDT. This review details the changes in physicochemical properties, enhanced homotypic cancer cell-selective endocytosis, improved tumor tissue targeting, and increased cytotoxicity and effective