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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1501381
This article is part of the Research Topic Clinical Pharmacist Service Promotes the Improvement of Medical Quality Volume II View all 22 articles

Effects of Pharmacogenomics-guided Treatment on Medication Adherence and the Rate of Antidepressant Switching in Major Depressive Disorder

Provisionally accepted
Chaoli Chen Chaoli Chen 1Yang Lun Yang Lun 1*Jing Yu Jing Yu 1,2Xiaochuan Zhao Xiaochuan Zhao 3*Shi Su Shi Su 1,4*Mengqiang Zhao Mengqiang Zhao 1Yuhang Yan Yuhang Yan 1*Jiaqi Wang Jiaqi Wang 1*Ran Fu Ran Fu 1*Feiyue An Feiyue An 5*Liguang Duan Liguang Duan 5*Leting Yan Leting Yan 3*Ruxing Li Ruxing Li 3*Jinxiao Li Jinxiao Li 3*Ziyu Liu Ziyu Liu 3*Xiaoying Geng Xiaoying Geng 6*Jincheng Wang Jincheng Wang 3*Yuanyuan Zhao Yuanyuan Zhao 4,7*Chunhua Zhou Chunhua Zhou 1,2*
  • 1 Department of Clinical Pharmacy, The First hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
  • 2 Department of The Technology Innovation Center for Artificial Intelligence in Clinical Pharmacy of Hebei Province, shijiazhuang, China
  • 3 Mental Health Center, The First hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
  • 4 Key Laboratory for Neuroimmunological Regulation and Mental Health of Hebei Province, shijiazhuang, China
  • 5 harmacy Department, The First Hospital of Hebei Medical University, shijiazhuang, China
  • 6 School of Pharmacy, Hebei Medical University,, shijiazhuang, China
  • 7 The First Hospital of Hebei Medical University, shijiazhuang, China

The final, formatted version of the article will be published soon.

    Background:In the treatment of depression, medication plays a crucial role.However, insufficient patient adherence to medication often results in unsatisfactory treatment outcomes, increasing both the recurrence and rehospitalization rates of depression, and consequently imposing a greater economic burden on the healthcare system. Objectives:Our objective was to examine the impact of pharmacogenomic testing on medication adherence and antidepressant switching rates among individuals diagnosed with depression. Methods:This retrospective cohort study encompassed patients diagnosed with depression who were admitted to the First Hospital of Hebei Medical University between April 2022 and September 2023. Patients were categorized into a pharmacogenomics-guided treatment (PGxT)group and a treatment as usual (TAU) group based on whether pharmacogenetic testing was conducted. The primary outcome measures included the proportion of patients exhibiting medication adherence greater than 80% at three and six months post-discharge, as well as the proportion of patients experiencing changes in their prescribed medication types. Results:A total of 310 patients in the PGxT group and TAU group were obtained through propensity score matching. Among the 620 patients in both groups, 57.42% demonstrated good adherence (≥ 80%) at three months; this percentage dropped to 31.45% at six months. At three months of observation, the percentages of patients demonstrating good adherence were significantly different between the groups (64.52% in the PGxT group vs. 50.32% in the TAU group; p < 0.001). The difference was also significant after six months (38.06% in the PGxT group vs. 24.84% in the TAU group; p < 0.001). Furthermore, patients receiving PGxT (20.64%) exhibited a lower rate of antidepressant conversion compared to those receiving TAU (31.29%). Conclusion:The findings of this study indicate that pharmacogenomics testing positively influences treatment adherence and may decrease the need to switch medications among patients with depression.

    Keywords: pharmacogenomics, adherence, switching, Depression, antidepressant

    Received: 25 Sep 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Chen, Lun, Yu, Zhao, Su, Zhao, Yan, Wang, Fu, An, Duan, Yan, Li, Li, Liu, Geng, Wang, Zhao and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yang Lun, Department of Clinical Pharmacy, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Xiaochuan Zhao, Mental Health Center, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Shi Su, Department of Clinical Pharmacy, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Yuhang Yan, Department of Clinical Pharmacy, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Jiaqi Wang, Department of Clinical Pharmacy, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Ran Fu, Department of Clinical Pharmacy, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Feiyue An, harmacy Department, The First Hospital of Hebei Medical University, shijiazhuang, China
    Liguang Duan, harmacy Department, The First Hospital of Hebei Medical University, shijiazhuang, China
    Leting Yan, Mental Health Center, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Ruxing Li, Mental Health Center, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Jinxiao Li, Mental Health Center, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Ziyu Liu, Mental Health Center, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Xiaoying Geng, School of Pharmacy, Hebei Medical University,, shijiazhuang, China
    Jincheng Wang, Mental Health Center, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Yuanyuan Zhao, The First Hospital of Hebei Medical University, shijiazhuang, China
    Chunhua Zhou, Department of Clinical Pharmacy, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China

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