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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1498728

Multifunctional Nanomaterials Composed Entirely of Active Pharmaceutical Ingredients for Synergistically Enhanced Antitumor and Antibacterial Effects

Provisionally accepted
Qi An Qi An 1Dongmei Wang Dongmei Wang 1Liang Huang Liang Huang 1Xiangyu Chen Xiangyu Chen 2*Chuan Wang Chuan Wang 1*
  • 1 Public Health and Clinical Center of Chengdu, Chengdu, China
  • 2 Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    The development of multifunctional nanomaterials has emerged as a promising strategy to address both cancer and bacterial infections. However, achieving dual therapeutic effects for cancer and bacterial treatment within a single system remains a challenge. Here, we developed multifunctional nanoparticles (ECI-NPs) through oxidative coupling reactions involving Epigallocatechin gallate (EGCG) oligomers, Curcumin (CUR), and Indocyanine Green (ICG). This nanomaterial enhances the photodynamic and photothermal effects of CUR and ICG, improving drug solubility and stability while promoting synergistic therapeutic outcomes. Physicochemical characterization of ECI-NPs demonstrated favorable stability, optimal particle size, high drug loading capacity, and controlled drug release profiles. Cellular studies revealed enhanced uptake and superior phototoxicity in melanoma cells when treated with ECI-NPs compared to free drugs. Additionally, the nanomaterial exhibited greater anticancer activity and potent antibacterial effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), surpassing the efficacy of individual components. The polyphenol-based nano-integrated platform presented in this study not only addresses the inherent limitations of the active pharmaceutical ingredients (APIs) but also demonstrates multiple synergistic functionalities. This approach holds great promise for broader biomedical applications, potentially offering innovative solutions for diverse therapeutic challenges.

    Keywords: combination, Curcumin, Antibacterial, anticancer, All API

    Received: 19 Sep 2024; Accepted: 09 Oct 2024.

    Copyright: © 2024 An, Wang, Huang, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiangyu Chen, Sichuan University, Chengdu, 610065, Sichuan Province, China
    Chuan Wang, Public Health and Clinical Center of Chengdu, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.