AUTHOR=Ta Giang H. , Leong Max K. 

TITLE=Mitigating Paxlovid™-induced drug‒drug interaction toxicity: an in silico insight

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1496630

DOI=10.3389/fphar.2024.1496630

ISSN=1663-9812

ABSTRACT=<p>The clinical drug-drug interaction side-effects of Ritonavir, an ingredient in Paxlovid™, have been documented, highlighting the need to explore alternative administration methods for Nirmatrelvir, another drug in the Paxlovid™ combination. In this study, the skin permeability potential of Nirmatrelvir was assessed using various <italic>in silico</italic> models. The prediction results suggest that Nirmatrelvir could be administrated via the transdermal route, offering a promising avenue to enhance the efficacy of anti-COVID-19 agents.</p>