This article is a correction to:
Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism
Hailun Xia
Xinhao Xu
Xiaohai Chen
Ren-ai XuA Corrigendum on
Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism
by Xia H, Xu X, Chen J, Wu H, Shen Y, Chen X, Xu R-a and Wu W (2024). Front. Pharmacol. 15:1403649. doi: 10.3389/fphar.2024.1403649
In the published article, there was an error in Figure 7 as published. During the mapping process, the wrong unit of concentration value was used. Previous mapping used mg/mL as the unit of concentration for the X-value, which is inconsistent with the unit used for the figure, and is now converted to μM. The resulting Ki-values change from 0.17 and 0.30 to 3.26 and 5.87, respectively. The corrected Figure 7 and its caption appear below.
Figure 7
Figure 7. Lineweaver-burk plot, secondary diagram of Ki inhibiting ivacaftor metabolism at different concentrations of nimodipine in RLM (A) and in HLM (B).
In the published article, there was an error in Table 2 as published. During the mapping process, the wrong unit of concentration value was used for Nimodipine. Previous mapping used mg/mL as the unit of concentration for the X-value, which is inconsistent with the unit used in the table, and is now converted to μM. The resulting Ki-values change from 0.17 and 0.30 to 3.26 and 5.87, respectively. The corrected Table 2 and its caption appear below.
Table 2
Table 2. The IC50 values and inhibitory effects of nisoldipine and nimodipine on ivacaftor metabolism in RLM and HLM.
In the published article, there was an error. During the mapping process, the wrong unit of concentration value was used. Previous mapping used mg/mL as the unit of concentration for the X-value and is now converted to μM. The resulting Ki-values change from 0.17 and 0.30 to 3.26 and 5.87, respectively.
A correction has been made to 3 Results, 3.3 Nisoldipine and nimodipine inhibited ivacaftor metabolism in RLM and in HLM through different inhibitory mechanisms. This sentence previously stated:
“The Ki values were 0.17 and 0.30, respectively (Table 2).”
The corrected sentence appears below:
“The Ki values were 3.26 and 5.87, respectively (Table 2).”
The authors apologize for these errors and state that these do not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: cystic fibrosis, ivacaftor, nisoldipine, nimodipine, drug-drug interaction, pharmacokinetics
Citation: Xia H, Xu X, Chen J, Wu H, Shen Y, Chen X, Xu R-a and Wu W (2024) Corrigendum: Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism. Front. Pharmacol. 15:1495855. doi: 10.3389/fphar.2024.1495855
Received: 13 September 2024; Accepted: 23 September 2024;
Published: 27 September 2024.
Edited and reviewed by:
Junmei Wang, University of Pittsburgh, United StatesCopyright © 2024 Xia, Xu, Chen, Wu, Shen, Chen, Xu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Wenzhi Wu, wwzljy@163.com; Ren-ai Xu, xra@wmu.edu.cn