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REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1495393

Hydroxysafflor Yellow A: A Natural Pigment with Potential Anticancer Therapeutic Effect

Provisionally accepted
Yuhan Wang Yuhan Wang 1,2Junsha An Junsha An 1,2Zhou Jianbo Zhou Jianbo 2,3Fu Peng Fu Peng 2,3*Liming Chang Liming Chang 2Quan Zhang Quan Zhang 4
  • 1 Department of Pharmacy, Sichuan University, Chengdu, China
  • 2 West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 3 Sichuan University, Chengdu, China
  • 4 Department of Anatomy and Histology and Embryology, Chengdu Medical College, Chengdu, Sichuan, China

The final, formatted version of the article will be published soon.

    Hydroxysafflor yellow A (HSYA), a natural pigment with a chalcone structure extracted from Carthamus tinctorius L. (Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atherosclerosis, cancer, and diabetes.However, no study has reported on the anticancer mechanisms of Hydroxysafflor yellow A (HSYA), a principal bioactive compound in safflower. This review discusses recent developments in the physicochemical properties and sources, pharmacological effects and mechanisms, pharmacokinetic progress, and safety of HSYA, focusing on the involvement of HSYA in the regulation of related pathways and mechanisms of apoptosis, autophagy, and the tumor immune microenvironment in a variety of cancers. This can serve as a theoretical basis for further research and development of HSYA, with insights into the mechanisms of anticancer signaling pathways.

    Keywords: Hydroxysafflor yellow A, Pharmacological effects, Anticancer effect, pharmacokinetic progress, Safety

    Received: 12 Sep 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Wang, An, Jianbo, Peng, Chang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fu Peng, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.