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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Drug Metabolism and Transport
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1494646

LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia

Provisionally accepted
Mihaela Butiulca Mihaela Butiulca 1,2,3Lenard Farczadi Lenard Farczadi 4*Silvia Imre Silvia Imre 4,5Camil Eugen Vari Camil Eugen Vari 6Laurian Vlase Laurian Vlase 7Bogdan Cordos Bogdan Cordos 8Leonard Azamfirei Leonard Azamfirei 2,9Lazar Alexandra Lazar Alexandra 1,2
  • 1 George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mures, Romania
  • 2 Department of Anesthesia and Intensive Care, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Targu Mures, Romania
  • 3 PhD Student, Doctoral School of Medicine and Pharmacy, I.O.S.U.D, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania, Targu Mures, Romania
  • 4 Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mureș, Romania
  • 5 Department of Analytical Chemistry and Drugs Analysis, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mureș, Romania
  • 6 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Târgu Mureș, Romania, Targu Mures, Romania
  • 7 Department of Pharmaceutic Technology and Biopharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania, Cluj Napoca, Romania
  • 8 Experimental and Imaging Studies, Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Târgu Mureș, Romania, Targu Mures, Romania
  • 9 Emergency County Hospital Targu Mures, Târgu-Mureş, Romania

The final, formatted version of the article will be published soon.

    Knowledge of drug pharmacokinetics and tissue distribution is precious for ensuring patient safety and optimizing treatments. The varied use of local anesthetics, as well as the fact that anesthetics can sometimes have low therapeutic indices and numerous adverse drug reactions, makes any novel pharmacokinetics information valuable. The present manuscript describes a pharmacokinetic study of ropivacaine carried out after plane block anesthesia on an animal model, using high sensitivity, accurate, and precise LC-MS/MS bioanalysis. Both plasmatic concentrations and tissue distribution of ropivacaine and its primary active metabolite were determined. The results showed a tissue affinity of the anesthetics, a clearance of ropivacaine mainly by hepatic metabolism, and the final, mainly renal excretion of the hydroxylated metabolite. While the results cannot simply and directly be transposed

    Keywords: Ropivacaine, pharmacokinetics, LC-MS/MS, Rats, HPLC

    Received: 11 Sep 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 Butiulca, Farczadi, Imre, Vari, Vlase, Cordos, Azamfirei and Alexandra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lenard Farczadi, Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mureș, Romania

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