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MINI REVIEW article

Front. Pharmacol.
Sec. Inflammation Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1493155
This article is part of the Research Topic The Mechanisms of Fibrotic Disorders and Pharmacological Therapies View all 6 articles

Research progress of knee fibrosis after anterior cruciate ligament reconstruction

Provisionally accepted
Yangyang Liang Yangyang Liang Qingqing Zhang Qingqing Zhang Youfei Fan Youfei Fan *
  • The Affiliated Bozhou Hospital of Anhui Medical University, Bozhou, China

The final, formatted version of the article will be published soon.

    Anterior cruciate ligament (ACL) injury is a common sports injury, and ACL reconstruction is an effective surgery for this trauma. Most cases gain good recovery after surgery, while some may experience knee stiffness, which is characterized by joint fibrosis, leading to reduced joint mobility, pain, and dysfunction. Currently, various researches have been conducted in unveiling the mechanisms of this condition, identifying pre-, intra-, and post-operative risk factors, as well as testifying the efficacy of different therapeutic methods against this condition. In this review, we summarized the current progress regarding the advancements in knee fibrosis after ACL reconstruction. The risk factors associated with knee fibrosis are systematically delineated, accompanied by an evaluation of the efficacy of various treatment modalities in both the prevention and mitigation of fibrosis. Furthermore, recommendations for future research directions are proposed, offering a foundational basis for subsequent investigations.

    Keywords: Anterior cruciate ligament injury, Anterior Cruciate Ligament Reconstruction, Knee fibrosis, Risk factors, Treatment

    Received: 08 Sep 2024; Accepted: 08 Oct 2024.

    Copyright: © 2024 Liang, Zhang and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Youfei Fan, The Affiliated Bozhou Hospital of Anhui Medical University, Bozhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.