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REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1491802

Targeting programmed cell death via active ingredients from natural plants: A promising approach to cancer therapy

Provisionally accepted
Qian Li Qian Li Yan Tong Yan Tong Jianxiang Chen Jianxiang Chen *Tian Xie Tian Xie *
  • Hangzhou Normal University, Hangzhou, China

The final, formatted version of the article will be published soon.

    Cancer is a serious public health problem in humans, and prevention and control strategies are still necessary. Therefore, the development of new therapeutic drugs is urgently needed. Targeting programmed cell death, particularly via the induction of cancer cell apoptosis, is one of the cancer treatment approaches employed. Recently, an increasing number of studies have shown that compounds from natural plants can target programmed cell death and kill cancer cells, laying the groundwork for use in future anticancer treatments. In this review, we focus on the latest research progress on the role and mechanism of natural plant active ingredients in different forms of programmed cell death, such as apoptosis, autophagy, necroptosis, ferroptosis, and pyroptosis, to provide a strong theoretical basis for the clinical development of antitumor drugs.

    Keywords: cancer therapy, Plant natural compound, programmed cell death, Pharmacology, Signaling Pathways

    Received: 05 Sep 2024; Accepted: 09 Oct 2024.

    Copyright: © 2024 Li, Tong, Chen and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jianxiang Chen, Hangzhou Normal University, Hangzhou, China
    Tian Xie, Hangzhou Normal University, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.