Skip to main content

REVIEW article

Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1491763

Functions of METTL1/WDR4 and QKI as m7G modification -related enzymes in digestive diseases

Provisionally accepted
Wenyan Zhou Wenyan Zhou 1Yan Yi Yan Yi 1Wenyu Cao Wenyu Cao 2Xiaolin Zhong Xiaolin Zhong 1Ling Chen Ling Chen 1*
  • 1 The First Affiliated Hospital, University of South China, Hengyang, China
  • 2 University of South China, Hengyang, Hunan Province, China

The final, formatted version of the article will be published soon.

    N 7 -methylguanosine (m7G) modification is one of the most prevalent forms of chemical modification in RNA molecules, which plays an important role in biological processes such as RNA stability, translation regulation and ribosome recognition. Methyl-transferation of m7G modification is catalyzed by the enzyme complex of methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4), and Quaking (QKI) recognizes internal m7G methylated mRNA and regulates mRNA translation and stabilization. Recent studies have found that m7G modification -related enzymes are associated with the onset and progression of digestive cancer, such as colorectal cancer, liver cancer, and other digestive diseases such as ulcerative colitis. This review will focus on the latest research progress on the roles of m7G methyltransferase METTL1/WDR4 and recognized enzyme QKI in digestive diseases.

    Keywords: m7G, METTL1, WDR4, QKI, Cancer, digestive diseases

    Received: 09 Sep 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Zhou, Yi, Cao, Zhong and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ling Chen, The First Affiliated Hospital, University of South China, Hengyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.