AUTHOR=Massariol Pimenta Tatiana , Carlos de Souza Josiany , da Silva Martins Bárbara , Silva Butzene Solenny Maria , Simões Padilha José Matheus , Ganho Marçal Milleny , dos Santos Elias Guilherme , Rangel Leticia Batista Azevedo 

TITLE=Emerging strategies to overcome ovarian cancer: advances in immunotherapy

JOURNAL=Frontiers in Pharmacology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1490896

DOI=10.3389/fphar.2024.1490896

ISSN=1663-9812

ABSTRACT=<p>Ovarian cancer is the second most common malignant neoplasm of gynecological origin and the leading cause of death from cancer in the female reproductive system worldwide. This scenario is largely due to late diagnoses, often in advanced stages, and the development of chemoresistance by cancer cells. These challenges highlight the need for alternative treatments, with immunotherapy being a promising option. Cancer immunotherapy involves triggering an anti-tumor immune response and developing immunological memory to eliminate malignant cells, prevent recurrence, and inhibit metastasis. Some ongoing research investigate potentially immunological advancements in the field of cancer vaccines, immune checkpoint blockade, CAR-T cell, and other strategies.</p>