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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1487940
This article is part of the Research Topic Combination Therapies in Cancer Treatment: Enhancing Efficacy and Reducing Resistance View all articles
Concurrent Immune Checkpoint Blockade for Enhanced Cancer Immunotherapy Utilizing Engineered Hybrid Nanovesicles
Provisionally accepted
Yuxuan Liu
1
Fuxu Yang
2
Zhimin Li
2
Ting Wang
3
Yeteng Mu
2
Yuxin Fan
2
Han Xue
2
Lili Huang
2
Xingang Guan
3*
Hongxia Feng
1- 1 First People's Hospital of Wenling, Wenling, China
- 2 Beihua University, Jilin, Jilin Province, China
- 3 Taizhou University, Taizhou, China
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, demonstrating unprecedented efficacy against advanced cancers. However, their clinical applications are significantly hampered by low overall response rates. Dual blockade of two immune checkpoints represents a promising strategy to enhance immunotherapeutic efficacy. In this study, we developed hybrid cell membrane nanovesicles adorned with PD-1 and SIRPα receptors for combination immunotherapy in melanoma. Our hybrid nanovesicles (PD-1/SIRPα NVs) demonstrated high specificity to PD-L1 and CD47 ligands, facilitating the phagocytosis of melanoma cells by macrophages. In a melanoma mouse model, PD-1/SIRPα NVs significantly suppressed 77% of tumor growth and elicited a robust antitumor immune response for immunotherapy. In conclusion, our findings highlight the promising potential of PD-1/SIRPα NVs as novel and effective ICIs for cancer immunotherapy.
Keywords: PD-1, SIRPα, cell membrane nanovesicle, Immune checkpoint blockade, cancer immunotherapy
Received: 29 Aug 2024; Accepted: 30 Oct 2024.
Copyright: © 2024 Liu, Yang, Li, Wang, Mu, Fan, Xue, Huang, Guan and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xingang Guan, Taizhou University, Taizhou, China
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