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REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1486264

Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles

Provisionally accepted
Deju Zhang Deju Zhang 1Ying Yuan Ying Yuan 2,3Juan Xiong Juan Xiong 3Qingdong Zeng Qingdong Zeng 3Yiming Gan Yiming Gan 1Kai Jiang Kai Jiang 4Ni Xie Ni Xie 3*
  • 1 The University of Hong Kong, Pokfulam, Hong Kong, SAR China
  • 2 Shenzhen University, Shenzhen, Guangdong Province, China
  • 3 Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
  • 4 Eastern Institute of Technology, Ningbo, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Breast cancer is the most frequently diagnosed and fatal cancer among women worldwide. Dairy protein-derived peptides and dairy products are important parts of the daily human diet and have shown promising activities in suppressing the proliferation, migration, and invasion of breast cancer cells, both in vitro and in vivo. Most of the review literature employs meta-analysis methods to explore the association between dairy intake and breast cancer risk. However, there is a lack of comprehensive summary regarding the anti-breast cancer properties of dairy protein-derived peptides, dairy products, and dairy protein-based nanoparticles as well as their underlying mechanisms of action. Therefore, the present study discussed the breast cancer inhibitory effects and mechanisms of active peptides derived from various dairy protein sources. Additionally, the characteristics, anti-breast cancer activities and active components of several types of dairy products, including fermented milk, yogurt and cheeses, were summarized. Furthermore, the preparation methods and therapeutic effects of various dairy protein-containing nanoparticle delivery systems for breast cancer therapy were briefly described. Lastly, this work also provided an overview of what is currently known about the anti-breast cancer effects of dairy products in clinical studies. Our review will be of interest to the development of natural anticancer drugs.

    Keywords: Milk-derived peptides, breast cancer, Nanoparticles, Apoptosis, Antibreast cancer

    Received: 25 Aug 2024; Accepted: 29 Oct 2024.

    Copyright: © 2024 Zhang, Yuan, Xiong, Zeng, Gan, Jiang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ni Xie, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.