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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1485861
This article is part of the Research Topic Gut Feelings: Investigating the Link Between Microbiota and Kidney Disease Progression View all 7 articles
Clerodendranthus spicatus [Orthosiphon aristatus (Blume) Miq.] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuricemic nephropathy
Provisionally accepted
Yang Wang
1*
Kaiwen Li
2*
Siya Yan
1*
Ge Li
1*
Meifang Cheng
1*
Qian Chen
3
Yuzheng WU
1
Dan Wang
1,2*
Tao Wang
3,4*- 1 State Key Laboratory of Chinese Medicine Modernization (Tianjin University of Traditional Chinese Medicine), Tianjin, China
- 2 Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 3 State key Laboratory of Component-based Chinese Medicine (Tianjin University of Traditional Chinese Medicine), Tianjin, China
- 4 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
The kidney damage caused by the deposition of uric acid in the kidneys is of urgent need for new treatment drugs due to its complex pathogenesis. Orthosiphon aristatus (Blume) Miq. also known as Clerodendranthus spicatus, which has a significant therapeutic effect on hyperuricemia nephropathy (HN), however, the specific mechanism of its action is still unknown. sterile HN mice, without the effect of gut microbiota, the uric acid lowering, antiinflammatory, and renal fibrosis improving effects of C.spicatus were significantly reduced.Our results demonstrated that C.spicatus could reduce uric acid levels, anti-inflammatory effects, and improve HN by regulating the gut microbiota. This provides a novel scientific basis for the clinical application of C.spicatus.
Keywords: Orthosiphon aristatus (Blume) Miq., Hyperuricemic nephropathy, Gut Microbiota, renal fibrosis, NLRP3 signaling pathway
Received: 25 Aug 2024; Accepted: 11 Nov 2024.
Copyright: © 2024 Wang, Li, Yan, Li, Cheng, Chen, WU, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yang Wang, State Key Laboratory of Chinese Medicine Modernization (Tianjin University of Traditional Chinese Medicine), Tianjin, China
Kaiwen Li, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Siya Yan, State Key Laboratory of Chinese Medicine Modernization (Tianjin University of Traditional Chinese Medicine), Tianjin, China
Ge Li, State Key Laboratory of Chinese Medicine Modernization (Tianjin University of Traditional Chinese Medicine), Tianjin, China
Meifang Cheng, State Key Laboratory of Chinese Medicine Modernization (Tianjin University of Traditional Chinese Medicine), Tianjin, China
Dan Wang, State Key Laboratory of Chinese Medicine Modernization (Tianjin University of Traditional Chinese Medicine), Tianjin, China
Tao Wang, State key Laboratory of Component-based Chinese Medicine (Tianjin University of Traditional Chinese Medicine), Tianjin, China
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