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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Renal Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1485072

Purple corn extract improves benign prostatic hyperplasia by inhibiting 5 alphareductase type 2 and inflammation in testosterone propionate-induced rats

Provisionally accepted
Arin Choi Arin Choi Hee-Hwan Lee Hee-Hwan Lee Jae-Yong Lee Jae-Yong Lee Sang Jae Park Sang Jae Park Byung-Hak Kim Byung-Hak Kim *
  • Central research institute, Medience Co. Ltd., Chuncheon, Republic of Korea

The final, formatted version of the article will be published soon.

    Benign prostatic hyperplasia (BPH) is a health issue caused by an enlarged prostate in older men. Its prevalence increases with age, and it results in urination-related problems. This works studied the effect of purple corn extract (PCE) on improving BPH symptoms using a testosterone propionate (TP)-induced rat model. PCE reduced the enlargement and weight of the prostate through the inhibition of the conversion of testosterone to dihydrotestosterone (DHT) by inhibiting 5-reductase type 2 (Srd5a2) in TP-induced BPH rats. In these rats, PCE decreased androgen receptor (AR) expression, AR-mediated signaling, and cell proliferation and increased apoptotic cell death. Finally, PCE exhibited anti-inflammatory activity through the regulation of the nuclear factor-kappa B (NF-B) and nuclear factor erythroid 2-related factor 2 (Nrf-2) axis. These results indicate that the Srd5a2 inhibition and anti-inflammatory activity are some of the beneficial effects of PCE that improve BPH symptoms.

    Keywords: purple corn extract, Cyanidin-3-O-glucoside, Benign prostatic hyperplasia, 5reductase type 2, androgen receptor, Inflammation

    Received: 23 Aug 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Choi, Lee, Lee, Park and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Byung-Hak Kim, Central research institute, Medience Co. Ltd., Chuncheon, Republic of Korea

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