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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1484040

The Potential of Terminalia chebula in Alleviating Mild Cognitive Impairment: A Review

Provisionally accepted
Gao Huimin Gao Huimin Lu Hanyu Lu Hanyu Fang Nengqiao Fang Nengqiao *Su Jinsong Su Jinsong *Li Rui Li Rui *Wenjun Wang Wenjun Wang Yi Zhang Yi Zhang
  • Chengdu University of Traditional Chinese Medicine, Chengdu, China

The final, formatted version of the article will be published soon.

    Terminalia chebula Retz. (T. Chebula, ཨ་#་ར།) is highly utilized in ethnic medicine. Its medicinal value is gradually being recognized and shows great potential in the improvement of mild cognitive impairment (MCI) disorders. Tibetan medicine theory classifies this type of disease as one of the "Jie Xie Syndrome (བ'ེ ད་*ེ ད།)." The role of T. Chebula in such diseases has been increasingly studied. This work aimed to elucidate the research progress of T. Chebula in alleviating MCI. The review offers a critical update on the current understanding of the effect of T. Chebula on MCI and highlights new opportunities for exploring its therapeutic potential. This review discusses the role of T. Chebula in alleviating MCI and provides a comprehensive overview of the traditional medicinal uses, chemical composition, toxicology, and quality control aspects of T. Chebula. This review covers 171 chemical constituents and 11 active constituents targeting MCI, such as flavonoids, which can alleviate MCI, primarily through its antioxidative, anti-inflammatory, and neuroprotective properties. T. Chebula shows potential as a natural medicine for the treatment and prevention of MCI.As an important part of ethnomedicinal resources, this work offers valuable insights for future research on T. Chebula-containing ethnomedicines. Research on traditional drug treatments, optimized treatment standards, improved societal knowledge about MCI, and development of an early detection system is essential to the diagnosis and treatment of MCI. These efforts will provide better treatment resources for patients with MCI.

    Keywords: Terminalia bellirica, MCI, Tibetan medicine, Safety evaluation, phytochemistry, Quality control, Traditional medicinal uses

    Received: 21 Aug 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Huimin, Hanyu, Nengqiao, Jinsong, Rui, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Fang Nengqiao, Chengdu University of Traditional Chinese Medicine, Chengdu, China
    Su Jinsong, Chengdu University of Traditional Chinese Medicine, Chengdu, China
    Li Rui, Chengdu University of Traditional Chinese Medicine, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.