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CASE REPORT article

Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1482154
This article is part of the Research Topic Therapeutic Advances in Lung Cancer and Chronic Inflammatory Lung Disease View all 14 articles

A rare cancer case with primary pleural epithelioid hemangioendothelioma diagnosed with thoracoscopic biopsy achieving disease control after 16 months -case report and literature review

Provisionally accepted
Ioannis S. Pateras Ioannis S. Pateras *Konstantinos Kostopanagiotou Konstantinos Kostopanagiotou Menelaos G. Samaras Menelaos G. Samaras Anna Koumarianou Anna Koumarianou Mina Koutrouli Mina Koutrouli Nikolaos Korodimos Nikolaos Korodimos Katerina Kampoli Katerina Kampoli Vasiliki Apollonatou Vasiliki Apollonatou Effrosyni D. Manali Effrosyni D. Manali Stylianos Loukides Stylianos Loukides Periklis Tomos Periklis Tomos Sotirios Tsiodras Sotirios Tsiodras Ioannis G. Panayiotides Ioannis G. Panayiotides
  • National and Kapodistrian University of Athens, Athens, Greece

The final, formatted version of the article will be published soon.

    Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular tumor. Pleural EHE (pEHE) is even more uncommon, with significant heterogeneity in clinical behavior, challenging diagnosis and treatment decisions. Herein, we present a 74-year-old woman admitted to the hospital with dyspnea, pleural effusion, and refractory euvolemic hyponatremia. Chest computed tomography revealed a large right-sided pleural effusion with irregular thickening of the parietal pleura and localized nodularity. Histologic evaluation of thoracoscopic pleural biopsy tissue confirmed the diagnosis of pEHE. Assessment of volume status suggested that hyponatremia was attributed to a paraneoplastic endocrine syndrome. Administration of the multi-target tyrosine kinase inhibitor Pazopanib was associated with disease control with the patient remaining free-of symptoms after 16 months of follow-up. This report adds to the knowledge base of this exceptionally rare entity highlighting the need for a multi-disciplinary approach.

    Keywords: Rare cancer, Thoracic tumor, paraneoplastic endocrine syndrome, thoracoscopic guided biopsy, Pleural epithelioid hemangioendothelioma, Management

    Received: 17 Aug 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Pateras, Kostopanagiotou, Samaras, Koumarianou, Koutrouli, Korodimos, Kampoli, Apollonatou, Manali, Loukides, Tomos, Tsiodras and Panayiotides. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ioannis S. Pateras, National and Kapodistrian University of Athens, Athens, Greece

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