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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1482130
This article is part of the Research Topic Terrestrial and Marine Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope - Volume II View all articles

Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate

Provisionally accepted
Cem Öziç Cem Öziç 1Erdal Ertaş Erdal Ertaş 2Fırat Baran Fırat Baran 2Ayşe Baran Ayşe Baran 3Elham Ahmadian Elham Ahmadian 4Aziz Eftekhari Aziz Eftekhari 5*Rovshan Khalilov Rovshan Khalilov 6Elvin Aliyev Elvin Aliyev 7
  • 1 Kafkas University, Kars, Kars, Türkiye
  • 2 Batman University, Batman, Batman, Türkiye
  • 3 Mardin Artuklu University, Mardin, Mardin, Türkiye
  • 4 Tabriz University of Medical Sciences, Tabriz, Iran
  • 5 Ege University, Bornova, İzmir, Türkiye
  • 6 Baku State University, Baku, Azerbaijan
  • 7 Lankaran State University, Lankaran, Azerbaijan

The final, formatted version of the article will be published soon.

    Nanotechnology has emerged as a multifaceted subject that makes use of nanocarriers to integrate notions of alternative drug delivery systems. The method of encapsulating the drug molecule in a carrier, such as a magnetic nanoparticle, is a promising development that has the potential to deliver the medicine to the site where it is intended to be administered. Over the past few years, bioactive compounds have garnered a lot of attention in the realm of scientific research due to the fact that they are extremely low in toxicity and possess exceptional properties. Morin is a pentahydroxyflavone obtained from the leaves, stems, and fruits of various plantsmainly from the Moraceae family exhibiting diverse pharmacological activities such as anti-inflammatory, anti-oxidant, and free radical scavenging and helps treat diseases such as diabetes, myocardial infarction and cancer.In this study, we conducted the synthesis of a nanocomposite with magnetic properties by coating biocompatible activated carbon obtained from okra plant leaves with magnetic nanoparticles. Characterization of the synthesized activated carbon-coated magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and zeta potential. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (Colorectal), MCF-7 (breast), U373 (brain), T98-G (Glioblastoma) cancer cell lines, and human umbilical vein endothelial cells healthy cell line. We studied the loading and release behavior of morin hydrate in the activated carbon-coated magnetic nanocomposite. Activated carbon-coated magnetic nanocomposite carriers can show promising results for the delivery of Morin hydrate drugs to the targeted site.

    Keywords: Morin hydrate, MCF-7, Anticancer activity, Magnetic nanocomposite, Drug Delievery

    Received: 17 Aug 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Öziç, Ertaş, Baran, Baran, Ahmadian, Eftekhari, Khalilov and Aliyev. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Aziz Eftekhari, Ege University, Bornova, 35040, İzmir, Türkiye

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.