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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1481272
This article is part of the Research Topic Effect of Herbal Medicines and Their Metabolites on Treating and Managing Osteolytic Diseases View all articles

The application prospects of Sacha Inchi (Plukenetia volubilis Linneo) in rheumatoid arthritis

Provisionally accepted
Min Wang Min Wang 1Yin-Hong Xiang Yin-Hong Xiang 2*Mei Liu Mei Liu 3*Shan Jiang Shan Jiang 1*Jia-Ying Guo Jia-Ying Guo 1*Xiao-Yan Jin Xiao-Yan Jin 4*Hui-Feng Sun Hui-Feng Sun 1*Ning Zhang Ning Zhang 1Zhi-Gang Wang Zhi-Gang Wang 1*Jian-xin Liu Jian-xin Liu 2*
  • 1 Heilongjiang University of Chinese Medicine, Harbin, China
  • 2 Hunan University of Medicine, Huaihua, Hunan Province, China
  • 3 University of South China, Hengyang, Hunan Province, China
  • 4 Xinjiang Medical University, Ürümqi, Xinjiang Uyghur Region, China

The final, formatted version of the article will be published soon.

    Sacha Inchi (Plukenetia volubilis L) (SI) is a traditional natural medicine from tropical rainforests of Amazon region in South America. As a raw material for edible oil, it has various pharmacological effects such as antioxidant, anti-inflammatory, hypolipidemia, and blood pressure lowering, which have attracted increasing attentions of pharmacists. This has prompted researchers to explore its pharmacological effects for potential applications in certain diseases. Among these, the study of its anti-inflammatory effects has become a particularly interesting topic, especially in rheumatoid arthritis (RA). RA is a systemic autoimmune disease, and often accompanied by chronic inflammatory reactions. Despite significant progress in its treatment, there is still an urgent need to find effective anti-RA drugs in regard to safety. This review summarizes the potential therapeutic effects of SI on RA by modulating gut microbiota, targeting inflammatory cells and pathways, and mimicking biologic antibody drugs, predicting the application prospects of SI in RA, and providing references for research aimed at using SI to treat RA.

    Keywords: Plukenetia volubilis Linneo, Sacha inchi, Rheumatoid arthritis, Inflammation, antioxidant, Gut Microbiota

    Received: 15 Aug 2024; Accepted: 04 Oct 2024.

    Copyright: © 2024 Wang, Xiang, Liu, Jiang, Guo, Jin, Sun, Zhang, Wang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yin-Hong Xiang, Hunan University of Medicine, Huaihua, 418000, Hunan Province, China
    Mei Liu, University of South China, Hengyang, 421001, Hunan Province, China
    Shan Jiang, Heilongjiang University of Chinese Medicine, Harbin, China
    Jia-Ying Guo, Heilongjiang University of Chinese Medicine, Harbin, China
    Xiao-Yan Jin, Xinjiang Medical University, Ürümqi, Xinjiang Uyghur Region, China
    Hui-Feng Sun, Heilongjiang University of Chinese Medicine, Harbin, China
    Zhi-Gang Wang, Heilongjiang University of Chinese Medicine, Harbin, China
    Jian-xin Liu, Hunan University of Medicine, Huaihua, 418000, Hunan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.