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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Pharmacoepidemiology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1480994

Drug-induced hearing disorders: a disproportionality analysis of the FAERS database

Provisionally accepted
Baojian Li Baojian Li *xiaoling hu xiaoling hu zichen yue zichen yue
  • Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China

The final, formatted version of the article will be published soon.

    Background: To evaluate and identify reports of adverse event related to hearing impairment with drugs approved in the past 20 years, to identify new adverse reaction signals related to hearing impairment that have not yet been reported, and to improve the safety of drug treatments. Methods: The adverse event report data from the FAERS database from the first quarter of 2004 to the fourth quarter of 2023 were retrieved. 'Hearing disorders' was used as the keyword to screen for drugs related to the adverse event. After standardizing the drug name and the adverse drug event name, the adverse event reports with hearing disorders as the main suspicion were collected, and the proportional imbalance algorithm was used to detect the potential signals of adverse event to hearing impairment of related drugs.The top five drugs with the highest number of reported adverse events to hearing impairment were: sacubitril/valsartan(2674)、 adalimumab(2479)、 etanercept(1834)、 tofacitinib(1812)、 apixaban(1600)， With the exception of adalimumab, the risk of hearing impairment is not mentioned in the instructions. The top five drugs for new signal strength are: pancuronium(n = 13

    Keywords: Hearing Disorders, Adverse event, FAERS, Disproportionality analysis, Signal mining

    Received: 15 Aug 2024; Accepted: 05 Nov 2024.

    Copyright: © 2024 Li, hu and yue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Baojian Li, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.