Liangyin Shu ¹ Kailin Li ¹ Suyu Yang ² Mengdie Hu ³ Xinrong Ming ³ Bingyuan Yan ¹ Liangjun Guan ³ Shunli Xiao ^3*

• ¹ Shandong Second Medical University, Weifang, China
• ² Baotou Medical College, Baotou, China
• ³ Hunan University of Medicine, Huaihua, Hunan Province, China

The botanical drugs of genus Duhaldea DC. have been traditionally utilized in folk medicine for the treatment of a wide array of illnesses, encompassing fractures, bone wounds, carbuncles and poisoning, bronchitis, bruises, giddy with hypertension of qi, and lung deficiency cough. The genus Duhaldea DC. comprises fifteen species widespread in Central, East and South-East Asia, seven species (two endemic) in China. The review aims to provide a systematic overview of ethnopharmacology, phytochemistry and pharmacology of the Duhaldea DC. and to explore the future therapeutic potential and scientific potential of this genus. The data were systematically gathered from books and scientific databases such as PubMed, Web of Science, Google Scholar, CNKI, Doctoral and master’s Theses. To date, a total of 352 metabolites have been isolated from this genus, and terpenoids, flavonoids, phenylpropanoids, and inositol angelates are the primary contributors to the pharmacological activities of Duhaldea DC. The crude extracts and isolated phytochemical metabolites from this genus have been shown to exhibit various pharmacological activities, including anti-inflammatory, antimicrobial, anti-osteoporotic activities, anticancer, antioxidant activities, etc. Despite notable advancements in our understanding of the chemical constituents and pharmacological properties of the genus Duhaldea DC., it is absolutely crucial to conduct additional research into the pharmacology and toxicology of these species to definitively ascertain their safety, efficacy, and quality.