Skip to main content

REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1479765

Role of salvianolic acid B in the treatment of acute ischemic stroke: a systematic review and meta-analysis of animal models

Provisionally accepted
Jiashan Wang Jiashan Wang 1Pingping Su Pingping Su 1Chenyu Wan Chenyu Wan 2Yingqi Xu Yingqi Xu 1Junyue Huang Junyue Huang 1Jianli Niu Jianli Niu 3Zhuqing Jin Zhuqing Jin 1*
  • 1 Zhejiang Chinese Medical University, Hangzhou, China
  • 2 Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China
  • 3 Memorial Healthcare System, Hollywood, Florida, United States

The final, formatted version of the article will be published soon.

    Background: Salvianolic acid B (Sal B) is potentially the most valuable water-soluble active component in Salvia miltiorrhiza. Its chemical formula contains multiple phenolic hydroxyl groups, so it has a strong antioxidant capacity. Objective: We aim to investigate the efficacy and the potential mechanism of Sal B in the treatment of acute ischemic stroke injury. Materials and methods: CNKI, VIP, WanFang, SinoMed, PubMed and Web of Science were searched for all the literature related to Sal B in the treatment of acute ischemic stroke before August 2024. The methodological quality was assessed using an inspection scale combining the CAMARADES checklist and the new STAIR criteria. Data were analyzed using RevMan5.4 software. Results: A total of 14 articles were included. Sal B could effectively reduce infarct size, neurological deficit score, brain edema index, and brain water content in cerebral ischemic animals. Sal Bcould not only increase the content of superoxide dismutase (SOD) and decrease the content of malondialdehyde (MDA) to achieve anti-oxidative stress, but also reduce the level of interleukin-1β (IL-1β) protein to achieve anti-inflammatory response, and reduce the number of TUNEL cells to reflect its anti-apoptosis effect. In addition, Sal B can improve energy metabolism by increasing the content of energy charge (EC) and phosphocreatine (PCr), and maintaining ion balance via Na + /K + ATPase activity, resulting in the neuroprotective effects against acute ischemic stroke injury.This study showed that Sal B could significantly protect against acute ischemic stroke injury, mainly through anti-oxidative stress, anti-inflammatory response, anti-apoptosis, improving energy metabolism, and stabilizing ion balance.

    Keywords: Salvianolic acid B1, acute ischemic stroke injury2, MCAO3, Neuroprotection4, Meta-analysis5

    Received: 12 Aug 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Wang, Su, Wan, Xu, Huang, Niu and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhuqing Jin, Zhejiang Chinese Medical University, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.