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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1477938
This article is part of the Research Topic Nano Pharmaceutical Materials Design and Therapeutic Application View all 5 articles

Mapping the Evolution and Research Landscape of Ferroptosis-Targeted Nanomedicine: Insights from a Scientometric Analysis

Provisionally accepted
Siyang Cao Siyang Cao 1,2,3Yihao Wei Yihao Wei 1,2,4,5Yaohang Yue Yaohang Yue 1,2,3Deli Wang Deli Wang 1,2,3*Jun Yang Jun Yang 6*Ao Xiong Ao Xiong 1,2,3Hui Zeng Hui Zeng 1,2,7*
  • 1 National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen City, China
  • 2 Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, China
  • 3 Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen City, China
  • 4 Department of Rehabilitation Science, The Hong Kong Polytechnic University, Hong Kong, China
  • 5 Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
  • 6 Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, China
  • 7 Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China

The final, formatted version of the article will be published soon.

    Objective: Notable progress has been made in "ferroptosis-based nano drug delivery systems (NDDSs)" over the past eleven years. Despite the ongoing absence of a comprehensive scientometric overview and up-to-date scientific mapping research, especially regarding the evolution, critical research pathways, current research landscape, central investigative themes, and future directions. Methods: Data ranging from January 1, 2012, to November 30, 2023, were obtained from the Web of Science database. A variety of advanced analytical tools were employed for detailed scientometric and visual analyses. Results: The results show that China significantly led the field, contributing 82.09% of the total publications, thereby largely shaping the research domain. Chen Yu emerged as the most productive author in this field. Notably, the journal ACS Nano had the greatest number of relevant publications. The study identified liver neoplasms, pancreatic neoplasms, gliomas, neoplasm metastases, and melanomas as the top five crucial disorders in this research area. Conclusion: This research provides a comprehensive scientometric assessment, enhancing our understanding of NDDSs focused on ferroptosis. Consequently, it enables rapid access to essential information and facilitates the extraction of novel ideas in the field of ferroptotic nanomedicine for both experienced and emerging researchers.

    Keywords: Global research trend, ferroptosis, Nano drug delivery systems, scientometrics, Visualized analysis

    Received: 08 Aug 2024; Accepted: 12 Sep 2024.

    Copyright: © 2024 Cao, Wei, Yue, Wang, Yang, Xiong and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Deli Wang, National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen City, China
    Jun Yang, Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, China
    Hui Zeng, National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen City, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.