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REVIEW article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1477409
This article is part of the Research Topic Reviews in Pharmacology of Anti-Cancer Drugs: 2023 View all 4 articles

RGD-Based Self-Assembling Nanodrugs for Improved Tumor Therapy

Provisionally accepted
Hongfei Jiang Hongfei Jiang 1*Bin Wang Bin Wang 1Dongmei Tang Dongmei Tang 1Jianqiao Cui Jianqiao Cui 1Jing Yu Jing Yu 2Zhu Guo Zhu Guo 1
  • 1 Qingdao University, Qingdao, China
  • 2 Qingdao Municipal Hospital, Qingdao, Shandong Province, China

The final, formatted version of the article will be published soon.

    RGD-based self-assembling nanodrugs are a promising advancement in targeted cancer therapy, combining the specificity of RGD peptides with the benefits of nanotechnology. These nanodrugs enhance tumor targeting and cellular uptake while reducing off-target effects. RGD peptides facilitate the self-assembly of stable nanostructures, ensuring efficient drug delivery.Despite their potential, challenges such as immunogenicity, stability, tumor heterogeneity, and manufacturing scalability need to be addressed. Future research should focus on improving biocompatibility, advanced targeting strategies, personalized medicine approaches, and innovative manufacturing techniques. Overcoming these challenges will pave the way for the successful clinical translation of RGD-based nanodrugs, offering more effective and safer cancer treatments.

    Keywords: RGD peptides, Self-Assembling Nanodrugs, tumor targeting, cancer therapy, integrin receptors

    Received: 07 Aug 2024; Accepted: 17 Sep 2024.

    Copyright: © 2024 Jiang, Wang, Tang, Cui, Yu and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hongfei Jiang, Qingdao University, Qingdao, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.