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REVIEW article

Front. Pharmacol.
Sec. Neuropharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1476558

Therapeutic Potential and Mechanisms of Stem Cells in Major Depressive Disorder: A Comprehensive Review

Provisionally accepted
Jiaqi Li Jiaqi Li *Yuqian Wang Yuqian Wang Yucheng Zhang Yucheng Zhang Mengran Liu Mengran Liu Xinao Rong Xinao Rong Jinlan Jiang Jinlan Jiang
  • Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Depression is a common affective disorder characterized by persistent low mood, diminished interest or pleasure in normally enjoyable activities, disturbances in sleep patterns, and suicidal ideation.Conventional treatments often yield unsatisfactory results and are associated with several adverse effects. However, emerging literature has highlighted the potential of stem cell (SC) transplantation as a promising avenue for treating depression owing to its favorable anti-inflammatory and neurotrophic properties. This review summarizes the therapeutic effects and underlying mechanisms associated with SC transplantation in depression, offering a conceptual framework for the future application of SCs in the clinical treatment of depression.

    Keywords: Depression, Stem Cells, mechanisms, Immunomodulation, review

    Received: 06 Aug 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Li, Wang, Zhang, Liu, Rong and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiaqi Li, Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.